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Paper Description


Gene frequencies of human platelet alloantigens 1-5 in Egyptian and Jordanian populations


Authors: Salem A.-H., Abdel Hamed A. S., Abdalla E. M., and Almawi W.
Abstract: Background. The human platelet alloantigens (HPA) polymorphysim arises from single base pair substitution and leads to changes in amino acid of glycoproteins expressed on platelet. The aim of this study was to determine the gene frequencies of the five common HPA (HPA-1 to -5) in Egyptians and Jordanians and to compare these data with those established for other populations.
Materials and Methods. HPA genotyping was done by polymerase chain reaction with sequence specific primers.
Results. The gene frequencies obtained in Egyptians were: HPA-1a/b, 0.767/0.233; HPA-2a/b, 0.759/0.241; HPA-3a/b, 0.704/0.296; HPA-4a/b, 1/0; HPA-5a/b, 0.728/0.272, and in Jordanians: HPA-1a/b, 0.821/0.179; HPA-2a/b, 0.877/0.123; HPA-3a/b, 0.660/0.340; HPA-4a/b, 1/0; HPA-5a/b, 0.795/0.205. The observed gene frequencies in both populations were in Hardy-Weinberg equilibrium. The gene frequencies for HPA-2b and HPA-5b among Egyptians were the highest reported among Arabs. Except for HPA-2, there was no significant difference in the distribution of HPA-1 to -5 between both populations.
Conclusion. Distribution of HPA alleles among Egyptians and Jordanians are similar to those reported for other Arabs. This study reports the first data on gene frequencies of HPA in Egyptians and Jordanians.
Published in: Blood Transfusion;DOI: 10.2450/2013.0220-12(Published online: 07/05/2013):
URL: http://www.bloodtransfusion.it/articolosing.aspx?id=000440
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