عربي
Skip Navigation Links
UniversityExpand University
CollegesExpand Colleges
CentersExpand Centers
Admin. UnitExpand Admin. Unit
StaffExpand Staff
StudentsExpand Students
 
Skip Navigation LinksHome Research Research Papers Paper Description    
 
Skip Navigation Links.
 
Paper Description


Comparison between the effect of propofol and midazolam on picrotoxin-induced convulsions in rat


Authors: Zuheir A. Hasan , Rima L. Abdel Razzak, Karem H. Alzoubi
Abstract: Propofol is a short acting intravenous anesthetic that has been used in the treatment of status epileptics.
However, the occurrence of seizures in epileptic and non-epileptic patients during recovery from propofol
induced anesthesia suggests that propofol may have proconvulsant effects.We have previously shown that
propofol displays anticonvulsant effects against picrotoxin (PTX) induced seizures during its peak sedative
effects. The purpose of the present study was to compare the time course of the effect of intravenous administration
of various doses (2.5, 5, and 10 mg/kg) of propofol and midazolam on PTX-induced seizures in
adult female Sprague–Dawley rats. The latency to onset of clonic seizures induced by intraperitoneal injection
of PTX was significantly increased by the highest dose of propofol and all doses of midazolam, suggesting
that both agents display anticonvulsant effects. The anticonvulsant effects of propofol (10 mg/kg) lasted
about 20 min and PTX-induced clonic seizures were observed thereafter and peaked within 30 min post
drug administration. Clonic seizures progressed rapidly to tonic seizures leading to high rate of PTXinduced
mortality. In midazolam (10 mg/kg) treated rats, clonic seizures were observed 25 min after
drug administration and the number of rats exhibiting clonic seizures was highest within 40 min. However,
clonic seizures did not progress into tonic seizures and thus, PTX-induced seizure related mortality was significantly
reduced. In conclusion, this study provides further evidence for the anticonvulsant effects of
propofol and midazolam against PTX-induced seizures. Furthermore, the data of the current study showed
that midazolam was more effective than propofol against PTX-induced tonic seizures.
Published in: Physiology & Behavior;128():114 - 118
URL: http://dx.doi.org/10.1016/j.physbeh.2014.01.027
i just cheated on my girlfriend sunpeaksresort.com i need to cheat on my girlfriend
my boyfriend cheated blog.fetish-kinks.com should i cheat on my boyfriend
i cheated on my boyfriend with a girl site how to cheat boyfriend
i had a dream my boyfriend cheated on me read i dreamt my boyfriend cheated on me
why does my husband cheat i have cheated on my husband i almost cheated on my husband
i cheated on my would my husband cheat just found out my husband cheated on me
i cheated on my boyfriend with a black guy link i have cheated on my boyfriend
woman affair site my husband cheated with a man
my wife cheated on me with my father link cheat wife
I cheated on my girlfriend boyfriend cheated on me why do men have affairs
why husband cheat on their wife click My boyfriend cheated on me
how often do women cheat on their husbands click reasons women cheat
mothers sex stories link free adult erotic stories online
why people cheat in relationships spnote.com want my wife to cheat
discount drug coupon americadeserveshonesty.com walgreens prescription coupons
rx pharmacy card walgreens photo coupon 10 cent prints free prescription drug card
walgreens coupon photo code blog.blinddude.com walgreens coupon code for prints
sumatriptan 100mg link doxycycline pill
apps for locating cell phones live gps tracking device track mobile phone location
tablett?k acyclovir open v?s?rolni zovirax
women who cheat with married men redsoctober.com women who love to cheat
viagra coupons mikemaloney.net viagra coupons free
cvs weekly coupons open off coupons
metronidazole 400mg go amoxicillin
viagra coupon liberitutti.info viagra coupon free
discount drug coupon pfizer viagra coupons coupon viagra
cialis discount coupon mba-institutes.com prescription discount coupons
coupon for free viagra allied.edu coupon for free viagra
can i take levitra viagra in same day can i take levitra viagra in same day can i take levitra viagra in same day
can i take flonase and claritin canitake.net can i take flonase and claritin
can i take antabuse and naltrexone can i take antabuse and naltrexone can i take antabuse and naltrexone
online cialis coupons click pet prescription discount card
gabapentin dosage schedule gabapentin dosage schedule gabapentin dosage schedule
cialis discounts coupons prescription discount coupons free prescription cards
cialis dosage amounts open cialis dose 40
acheter viagra en ligne par http://acheterviagraenfrance.com/en/ligne-par acheter viagra en ligne par
buy generic cialis lipseysguns.com cialis discount card
coupons for prescription drugs sporturfintl.com free discount prescription cards
cialis sample coupon eblogin.com prescription drug cards
lilly cialis coupons cialis manufacturer coupon cialis.com coupons
augmentin duo augmentin augmentin bis
viagra szedése survivingediscovery.com viagra kamagra
risperdal warpedfish.co.uk risperdaloro
cialis open cialis
lamisil comprimidos lamisil comprimidos lamisil 1
etodolac 400 read etodolac recreational use
augmentin injectable augmentin augmentin sirop
prednisolone dosage for chest infection site prednisolone and alcohol a comprehensive view
cialis walgreen coupon go cheap cialis
prescription card discount click cialis coupons from lilly
manufacturer coupons for prescription drugs prescription drug coupons free prescription drug discount card
abortion legal protectedareas.info abortion laws by state
discount coupon for cialis site coupons for prescription drugs
free abortion pill open abortion clinics in memphis tn
arguments against abortion alpinmontservis.cz abortion pills over the counter
cialis coupon lilly prescriptions coupons cialis manufacturer coupon
cialis.com coupons cialis coupon free cialis manufacturer coupon
coupons for cialis 2015 cialis coupon free cialis samples coupon
amlodipine amlodipine dosage amlodipine benazepril
voltarene 100 voltarene 100 voltarenactigo
cialis free sample coupons pristineschool.com lilly coupons for cialis
discount coupon for cialis discount coupons for prescriptions printable cialis coupon
abortion clinics in the bronx why abortion is wrong what to expect after an abortion
prescriptions coupons cialis coupon lilly new prescription coupons
prescription discount coupon lakeerengallery.com lilly coupons for cialis
amoxicillin 1000 mg amoxicillin dermani haqqinda amoxicillin-rnp
cialis coupons from lilly ambito20.it prescription transfer coupon
average abortion pill cost acnc.com abortion price
abortion pill pictures 2nd trimester abortion pill late term abortion pill clinics
coupon for prescriptions funtimeleisure.co.uk coupons for prescription medications
abortion pill cost how late can you get an abortion pill home abortion pill
how much do abortion pill cost abortions facts should abortion pill be legal
manufacturer coupons for prescription drugs discount coupons for prescriptions coupons cialis
free cialis coupon 2016 ambito20.it cialis prescription coupon
printable cialis coupon prescription drug coupons cialis free sample coupons
coupons for prescription drugs sfmcouriers.com prescriptions coupons
price of crestor 10 mg crestor 10 mg crestor retail price
aerius aerius 10mg aerius avis
new prescription coupon free coupon for cialis coupon cialis
losartankalium losartankalium losartan jubilant
how much is an abortion pill abortion pill facts abortion pill questions
amoxicillin endikasyonlar amoxicillin 500 mg amoxicillin antibiyotik fiyat
buscopan tropfen buscopan dragees buscopan 10mg
vermox prezzo exlim.net vermox tablete cijena
vermox sirup cijena vermox vermox doziranje
champix dosis pallanuoto.dinamicatorino.it champix inicio
freie potenzmittel potenzmittel rezeptfrei apotheke viagra generika rezeptfrei
allods online allow alloy
teenage abortions pregnancy 2 weeks abortion in the first trimester
2015 cialis coupon cialis sample coupon cialis discount coupons
prescription transfer coupon prescription cards get free coupons
abortion pill centers where to get an abortion pill late term abortion pill
acetazolamide migraine acetazolamide blood brain barrier acetazolamide pka
viagra online viagra viagra online
coupons website coupon websites for groceries online free coupons
late term abortion pill clinics abortion pill cost without insurance abortion pill articles
acetazolamide spc acetazolamide migraine acetazolamide symptoms
amoxicillin nedir amoxicillin al 1000 amoxicillin 500 mg
amoxicillin-rnp aictmkulahospital.org amoxicillin 500 mg
amoxicillin-rnp amoxicillin 1000 mg amoxicilline
metoprololsuccinat hexal 50 mg mipnet.dk metoprololsuccinat hexal 50 mg
lilly cialis coupon activeslo.com cialis coupons and discounts
cialis online coupon cialis trial coupon lilly cialis coupon
metoprolol pro medicin metoprolol tartrate metoprololsuccinat hexal 50 mg
clomid proviron eblogin.com clomid proviron
abortion pill definition britmilk.co.uk teen abortion pill
abortion pill side effects supermaxsat.com abortion pills cost
abortion pill costs alpinmontservis.cz average abortion pill cost
abortion pill recovery cons of abortion pill free abortions
abortion pill the abortion pill cost abortion price
vermox 100mg vermox vermox tablete nuspojave
free abortion pill teenage abortion pill abortions facts
non surgical abortion pill albayraq-uae.com where to get an abortion pill
acetazolamide blood brain barrier blog.bjorback.com acetazolamide blood brain barrier
anti abortion facts angkortaxiservice.com how does an abortion pill work
Copyright © 2010 Arabian Gulf University Contact: Tel:17239999, Fax:17272555 | Home | Location | site map| عربي |