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Paper Description


Les lectines de type C de venins de serpents et leurs récepteurs sur les plaquettes et les cellules cancéreuses


Authors: S. SARRAY, J. LUIS 4, M. EL AYEB 1 ET N. MARRAKCHI
Abstract: Summary
Snake venoms are a rich natural source of bioactive molecules, such as peptides, proteins and enzymes, more and more used in biomedical research in diagnostic or therapeutic purposes. The protein components of snake venoms belong to diverse
families such as serine proteases, phospholipases, disintegrins, metalloproteinases and C-type lectins. Due to their effects on various receptors such as GPIb, GPVI, a2ß1…, the C-type lectins were considered, in first time, as modulators of the platelet aggregation. Recently, some of them have been described for their anti-tumoral potential effect due to their capacity to inhibit adhesion, migration, proliferation and invasion of different cancer cell
lines. Also, the C-type lectins have a powerful antiangiogenic effect in vivo and in vitro by interacting with integrins of endothelial cells.
Published in: Pasteur Institute Archive;85(1-4):69-80
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