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Paper Description


Anti-tumor snake venoms peptides


Authors: Sameh SARRAY, Raoudha ZOUARI, Jed JEBALI, Ines LIMAM, Amine BAZAA, Maram MORJANE, Zeineb ABDELKAFI, et al
Abstract: Snake venoms contain more than 100 different proteins and peptides which are an important source of biomolecules that selectively target several membrane receptors, such as cell adhesion molecules (integrins, cadherins …). International research and development in this area, based on multidisciplinary approaches including molecular screening, proteomics, genomics and pharmacological tests in vitro, ex vivo and in vivo, allowed the identification and characterization of highly specific molecules. Since recently, several peptides and peptidomimetics are used as medicament, such as cilengitide based on RGD motif, which targets specifically glioblastoma and actually is in clinical trial III. For over twenty years, the Laboratory of Venoms and Toxins from Pasteur Institute of Tunis has characterized from Macrovipera lebetina and Cerastes cerastes venoms, several peptidic molecules with pharmacological potencies. These molecules belong to different families (phospholipases, disintegrins, C-type lectins and metalloproteinases). We have demonstrated that these proteins present anti-tumoral, anti-angiogenic and/or pro-apoptotic activities. Our results show that C-type lectin and phospholipases A2 interact with alpha 5 beta 1 and alpha v integrins whereas lebestatin, a small disintegrin, targets alpha 2 beta 1 integrin, a collagen receptor.
Published in: Meeting on toxinology;SFET Edition():127-132
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