عربي
Skip Navigation Links
UniversityExpand University
CollegesExpand Colleges
CentersExpand Centers
Admin. UnitExpand Admin. Unit
StaffExpand Staff
StudentsExpand Students
 
Skip Navigation LinksHome Research Research Papers Paper Description    
 
Skip Navigation Links.
 
Paper Description


Lebectin and lebecetin, two C-type lectins from snake venom, inhibit a5ß1 and av-containing integrins


Authors: Sameh Sarray, Estelle Delmarre, Jacques Marvaldi, Mohamed El Ayeb, Naziha Marrakchi and José Luis.
Abstract: Integrins are essential protagonists in the complex multistep process of cancer progression and metastasis. We recently reported that lebectin, a
novel C-type lectin from Macrovipera lebetina venom, displays an anti-integrin activity. In this study, we extend this observation to lebecetin, a
second C-type lectin isolated from the same venom and previously reported as a potent inhibitor of platelet aggregation. Both venom lectins
appear to exert their effect on cell adhesion, migration, invasion and proliferation by inhibiting a5ß1 and av-containing integrins. Moreover, the
inhibition of a5ß1 and av integrins is likely due to the binding of venom peptides, as both lebectin and lebecetin co-immunoprecipitate with these
integrins. Lebectin and lebecetin are thus the first examples of venom C-type lectins inhibiting an integrin other than the collagen receptor a2ß1.
© 2007 Elsevier B.V./International Society of Matrix Biology. All rights reserved.
Published in: Matrix Biology;26(4):306-313
URL:
Copyright © 2010 Arabian Gulf University Contact: Tel:17239999, Fax:17272555 | Home | Location | site map| عربي |