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Paper Description


Lebecin, a new snaclec from Macrovipera lebetina venom with anti-tumour activity on breast cancer cells


Authors: Jed Jebali, Emna Fakhfekh,Morgen Maram, Srairi-Abid Najet, Majdoub Hatem, Gargouri Ali, (...) Sameh Sarray
Abstract: C-type lectins like proteins display various biological activities and are known to affect especially platelet aggregation. Few of them have been reported to have anti-tumor effects. In this study, we have identified and characterized a new C-type lectin like protein, named lebecin. Lebecin is a heterodimeric protein of 30 kDa. The N-terminal amino acid sequences of both subunits were determined by Edman degradation and the entire amino acid sequences were deduced from cDNAs. The precursors of both lebecin subunits contain a 23-amino acid residue signal peptide and the mature a and b subunits are composed of 129 and 131 amino acids, respectively. Lebecin is shown to be a potent inhibitor of MDAMB231 human breast cancer cells proliferation. Furthermore, lebecin dose-dependently inhibited the integrin-mediated attachment of these cells to different adhesion substrata. This novel C-type lectin also completely blocked MDA-MB231 cells migration towards fibronectin and fibrinogen in haptotaxis assays.
Published in: Toxicon;():16-27
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