عربي
Skip Navigation Links
UniversityExpand University
CollegesExpand Colleges
CentersExpand Centers
Admin. UnitExpand Admin. Unit
StaffExpand Staff
StudentsExpand Students
 
Skip Navigation LinksHome Research Research Papers Paper Description    
 
Skip Navigation Links.
 
Paper Description


Increased serum levels of tumor necrosis factor-a and interleukin-6 in adult Bahraini sickle cell disease patients with hypovitaminosis D and low bone mineral density


Authors: Hassan AB, Garadah T, Diab DE, Sequeira RP, Jaradat A, Nasser AS, Al Qurashi F
Abstract: Objective: To investigate serum levels and relationship between tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), C-reactive protein (CRP), bone mineral density (BMD) and vitamin D in Bahraini sickle cell disease (SCD) patients compared to healthy controls. Methods: Seventy patients with SCD followed at department of hematology at Salmaniya Medical Complex and 70 sex-matched healthy controls were included prospectively in this study. Serum levels were measured using ELISA kits for cytokines and UPLC-MS for vitamin D. BMD was estimated using Dual Energy X-ray Absorptiometry (DEXA). Osteopenia (T score < -1>-2.5) and osteoporosis (= -2.5) were diagnosed as per WHO criteria. Results: SCD patients had increased serum levels of TNF-a (56.72 pg/ml; range 27.43-98.93) compared to controls (39.49 pg/ml; range 27.56-119.95; p<0.0001). Our patients had increased serum levels of IL-6 (49.5 pg/ml; range 12.27-101.81) compared to controls ( 30.08 pg/ml; range 4-275; p=0.002). While, 94% of patients had low vitamin D, only 6% had optimal levels. However, 58% of patiens had abnormal BMD and 42% had normal BMD. A positive correlation between vitamin D and TNF-a (r=0.333, p=0.005) and vitamin D and CRP (r=0.265, p=0.027) were found, but not between vitamin D and BMD. Conclusions: The presence of low-grade inflammation in Bahraini SCD patients in steady-state is suggested by increased levels of proinflammatory cytokines and CRP. The cytokines (TNF alpha and IL-6) serum levels were associated with hypovitaminosis D. Vitamin D and BMD tests should be offered to all SCD patients for early intervention, if indicated.
Published in: International Journal of Current Research;7(9):20702-20707
URL: http://www.journalcra.com/article/increased-serum-levels-tumor-necrosis-factor-%CE%B1-and-interluekin-6-adult-bahraini-sickle-cell-
Copyright © 2010 Arabian Gulf University Contact: Tel:17239999, Fax:17272555 | Home | Location | site map| عربي |