Instructor's Portfolio

Dr. SAMEH SARRAI HLOUI


Assistant Professor

College of Medicine and Medical Sciences
BioChemistry Section
Office Tel. +973-17239412
 



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Qualifications

Qualifications

- Faculty of Sciences; University of Tunis / Habilitation [State Doctorate in Biological Sciences] Tenure Track Review / 2010
- Faculty of Sciences; University of Tunis / PhD in BIOCHEMISTRY / 1999-2003
- Pasteur Institute of Paris, France / GRADUATE DIPLOMA IN PROTEIN CHEMISTRY / 2000
- Faculty of Sciences University of Tunis / MASTER in GENETIC & MOLECULAR BIOLOGY / 1997-1998
- Faculty of Sciences; University of Tunis / Bachelor in Biological Sciences / 1992-1996

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Work Experience

Experience

- ASSISTANT at the Faculty Sciences, University of Tunis, Tunisia, 2003-2005
- ASSISTANT PROFESSOR OF BIOCHEMISTRY at the Faculty Sciences, University of Tunis, Tunisia, 2006-2013

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Scientific Production

Publication

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Teaching Courses

Teaching Courses

- Metabolic & Structural biochemistry
- Structure-function of proteins
- Molecular biology
- Biochemistry analysis
- Toxicology

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Academic Supervision

Supervised the following theses

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Committees

 

Attendance in most important committees within the university

 - BSc. Committee: March 2015 - Present
- Year 3 Unit VI: March 2015 - June 2015
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Research Interests

 

• Study of changes in the levels of anti-inflammatory cytokines in pediatric sickle cell disease patients with osteomyelitis
• Levels of pro-inflammatory cytokines in pediatric sickle cell disease
• Adipokines as a marker of polycystic ovary syndrome
• Interaction of adhesion proteins in the migration, proliferation, and invasion of certain cancer cell lines.
• Role played by adhesion proteins on angiogenesis and reorganization of the cytoskeleton of certain cancer cell lines (cadherin - catenins complex, actin .....).
• Relocation and signal transduction of cadherins in cancer cell lines.
• Purification and characterization of snake venom proteins.

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Lectures/Seminars/Workshops

 

 Oral Presentations:
- Sameh SARRAY, sorokine O, van Dorsseler A. El Ayeb M, et Marrakchi N. Les lébétanes, une nouvelle famille d’anti-agrégants plaquettaires du venin de Macrovipera lebetina. The 10th days of the Tunisian Association of Biology Monastir-March 1999.

- Sameh SARRAY, Srairi N, Luis J, Marvaldi J, El Ayeb M et Marrakchi N. Purification et caractérisation d’une protéine du venin de Macrovipera lebetina a effet anti-agrégant plaquettaire et anti-adhérant de trois types de cellules cancéreuses. The 11th days of the Tunisian Association of Biology Hammamet-March 2000.

- Marrakchi N, Luis J, Sameh SARRAY, Marvaldi J et El Ayeb M. Effet des venins de Macrovipera lebetina et de Cerastes cerastes sur l’adhérence de trois types de cellules cancéreuses sur plusieurs matrices cellulaires. The 11th days of the Tunisian Association of Biology Hammamet-March 2000.

- Sameh SARRAY, Srairi N, Luis J, Marvaldi J., El Ayeb M et Marrakchi N. Lebecetin, a novel platelet aggregation inhibitor from the venom of Macrovipera lebetina. XIIIth Congress on animal, plant and microbial toxin Inter. Soc on Toxicology, Paris–Sept. 2000.

- Sameh SARRAY, Luis J, Srairi N, Reagaya I, Marvaldi J, El Ayeb M et Marrakchi N. La lébécétine, une protéine de type C-lectine, antagoniste de l’agrégation et l’agglutination plaquettaire, inhibitrice de l’adhésion et la migration de certaines lignées cellulaires cancéreuses, isolée à partir du venin de Macrovipera lebetina. The 12th days of the Tunisian Association of Biology Hammamet-March 2001.

- Sameh SARRAY, Luis J, Srairi N, Marvaldi J, El Ayeb M et Marrakchi N. Lebecetin, a novel C-lectin protein from the venom of Macrovipera lebetina that affect platelet aggregation and adhesion of cancerous cells. International conference on Exogenous Factors affecting Thrombosis and Haemostasis (EFTH). PARIS–July 2001.

- Sameh SARRAY, Luis J, Marvaldi J, El Ayeb M et Marrakchi N. Propriétés antiplaquettaire et antiadhésive d’une lectine de type C: La lébécétin. The 13th days of the Tunisian Association of Biology Hammamet-March 2002.

- Sameh SARRAY, Luis J, Bazaa, A., Zouari, R., Marvaldi J, El Ayeb M et Marrakchi N. L’IPML: une protéine purifiée à partir de venin de vipère tunisienne (Macrovipera lebetina) à effet anticancéreux potentiel. The 14th days of the Tunisian Association of Biology Hammamet-March 2003.

- Zouari R, Sameh SARRAY, Srairi N, Ayad S, Bazaa A, Marvaldi J, Luis J, El Ayeb M et Marrakchi N. Purification et caractérisation d’une désintégrine à partir de venin de Cerastes cerastes douée d’activité antiplaquettaire et antiadhésive. The 14th days of the Tunisian Association of Biology Hammamet-March 2003.

- Sameh SARRAY, Luis J, Zouari R, Marvaldi J, El Ayeb M., Marrakchi, N. Etude des effets de la lébécétine, une C-lectine protéine sur la prolifération, la migration et l’invasion de certaines lignées de cellules cancéreuse. The 15th days of the Tunisian Association of Biology Hammam-Sousse March 2004.

- Bazaa A, Srairi N, Ziri Kallech O, Faure G, Sameh SARRAY, El Ayeb M et Marrakchi N. Purification et caractérisation de la MVL (PLA2) à partir du venin de Macrovipera lebetina, Mise en évidence d’un inhibiteur naturel. The 15th days of the Tunisian Association of Biology Hammam-Sousse March 2004.

- Zouari R, Sameh SARRAY, Marvaldi J, El Ayeb M., Marrakchi N, Luis J. Effet antiadhésive sur certaines lignées cancéreuses de deux désintégrines CC5 et CC8 purifiées à partir du venin de la vipère à corne: Cerastes cerastes. The 15th days of the Tunisian Association of Biology Hammam-Sousse March 2004.

- Sameh SARRAY, Luis J, Marvaldi J, El Ayeb M, Marrakchi N. Etude des effets biologiques de la lebectine, une lectine de type-C issue du venin de Macrovipera lebetina, sur certaines lignées de cellules cancéreuses. International Congress of Biochemistry Marrakech-May 2004.

- Sameh SARRAY, Elodie DR, El Ayeb,M., Marrakchi N et Luis J. Effet de la lebectine, une C-lectine issue du venin du venin de Macrovipera lebetina sur la réorganisation du cytosquelette des cellules mélanomateuses IGR39. The 16th days of the Tunisian Association of Biology Hammamet–March 2005.

- Sameh SARRAY, Pilogret A, Daoud S, Beliveau R, El Ayeb M, Luis J et Marrakchi N. Etude de l’effet de la lebectine, une C-lectine protéine sur l’angiogenèse in vivo et in vitro. The 17th days of the Tunisian Association of Biology Hammamet–March 2006.

- Jebali J, Bazaa A, Sameh SARRAY, Abdejelil S, El Ayeb M, Marrakchi N, Gargouri A. Clonage et Séquençage des Protéines Appartenant à la Famille des Lectines de Type C issues de Venin de Macrovipera lebetina. The 18th days of the Tunisian Association of Biology Hammamet–March 2007.

- Sameh SARRAY, El Ayeb M, Frederic Andre, José LUIS, and Naziha Marrakchi. Snake C-type lectins: a promising molecules with anti-tumoral progression and anti-platelet aggregation. EPS MONTREAL BIOMEDECINE FORUM Montreal, CANADA 3-4 November 2011.

- Sameh SARRAY, Raoudha ZOUARI, Jed JEBALI, Amine BAZAA, Maram MORJANE, Zeineb ABDELKEFI, Olfa ZIRI, Najet Srairi, Salma DAOUED, José LUIS, Mohamed El AYEB and Naziha MARRAKCHI.. Anti-tumor snake venoms peptides. Meeting on toxicology. Paris-France 28-29 November 2011.

- Sameh SARRAY, Raoudha ZOUARI, Jed JEBALI, Amine BAZAA, Maram MORJANE, Zeineb ABDELKEFI, Olfa ZIRI, Najet SRAIRI, Salma DAOUED, José LUIS, Mohamed El AYEB and Naziha MARRAKCHI.. Anti-tumor snake venoms peptides. Tunisian Days of Biotechnology 19-22 December 2011.

- Sameh SARRAY, Jed JEBALI, Andre FREDERIC, Mohamed El AYEB, José LUIS Naziha Marrakchi. Effet anti-tumoral et anti-angiogénique de deux lectines de type C du venin de serpents. Congress of Toxicology Tabarka, 3-5 Février 2012

- Sameh SARRAY, Jed JBALI, Emna FAKHFEKH, Mohamed EL AYEB, Naziha MARRAKCHI. Lebecin, a novel snaclec from Macrovipera lebetina venom with anti-tumour activity on breast cancer cells (MDA-MB231). 1st Oxford world Symposium on venoms. Oxford-London, 18-20 September 2012.

Poster Presentations:
- Bazaa A, Srairi N, Ziri O, Sameh SARRAY, Zouari R, El Ayeb M and Marrakchi, N. Purification, Caractérisation et séquençage d’un fragment N-terminal d’une phospholipase A2 du venin de Macrovipera lebetina. The 14th days of the Tunisian Association of Biology Hammamet–March 2003.

- Sameh SARRAY, Pilorget, A, Ziri, O, Zouari R, Lehmann M, Berthet V, Calvete JJ, Béliveau R, El Ayeb M, Marrakchi N et Luis J. Snake venoms- a cornucopia for potent anti-integrin peptides. 2nd Days of Research of the University of Pharmacy of Marseille Marseille–March 2005.

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Office Tel. +973-17239412
 

 

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