HIGH PROFILE TESTS -NUTRIGENOMICS AND FITNESS

 

​​​DNA Health, Mind, Diet, Sport and Oestrogen

Combination DNA tests : Health, Mind, Diet, Sport and Oestrogen. Please see individual test pages for full description of test content and genes analysed.

DNA Health: Gene variations associated with metabolic and biological processes.  
 

The DNA Health test is designed to optimise well-being and health by personalising lifestyle and diet choices and, where necessary, using supplements tailored to offset any particular nutritional deficit based on specific gene variants.

​The DNA Health approach assists the healthcare practitioner in establishing the optimal nutrition necessary for good health, longevity and disease risk mitigation. Diet is a key factor in determining genomic stability as it impacts on all relevant pathways:  exposure to dietary carcinogens, biotransformation, DNA repair and synthesis, and apoptosis. Current recommended dietary allowances for vitamins and minerals are based largely on the prevention of diseases of deficiency. However, because diseases of lifestyle are partly caused by damage to DNA it stands to reason that we should focus our attention on defining optimal requirements of key minerals and vitamins for preventing genomic instability. 

Additional attention should be paid to individuals with genetic polymorphisms that alter the bioavailability of specific micro-nutrients and the affinity of specific key enzymes for their micro-nutrient co-factor. 

Clinical Value

  • Highlights specific metabolic pathways that may require extra support
  • Provides recommendations that involve optimisation of quantities of certain nutrients, vitamins and minerals
     
  • Suggests whether an individual is better able to reduce their cholesterol levels through diet, as opposed to through medication
     
  • Provides an indication of the degree of susceptibility to the harmful effects of carcinogens ingested in the diet
     

​The DNA Health Test Report provides:
 

  • The level of impact of any genetic variants identified
  • An explanation of their impact on health
     
  • Appropriate nutritional and lifestyle recommendations
     

​The results are divided in sections of key metabolic function, so that genetic weaknesses and strengths within a functional area can be easily identified.
 


 

DNA Diet: Genes that impact metabolism, diet and excerise.  
 

 

Indications Overview Practical Research

One of the first products of its kind in the world, DNA Diet tests for 15 genes that impact metabolism and exercise. The genes comprising the DNA Diet test have associations with body weight and body mass index, and all meet stringent criteria for utility in genetic screening tests.  We provide a detailed report with recommendations that include dietary changes and an exercise programme.
 

Genes involved in regulation of energy expenditure, appetite, and fat metabolism, all play an important role in weight regulation. In fact 40% to 80% of the variance in body weight is due to genetic factors. This helps to explain why not everyone gains or loses weight while following the same diet, despite being exposed to similar environments. Identifying an individual’s responsiveness to diet and lifestyle modification to control weight can be extremely advantageous. 

Genetics determines an individual’s susceptibility to obesity when exposed to an unfavourable environment. It also explores the way a person responds to diet and exercise.​

While healthy nutrition may in certain cases result in weight loss, this depends on many factors. The DNA diet provides a tailor made nutrition and exercise programme. Healthy eating and exercise may result in weight loss, but this is not guaranteed. 

Clinical Value

  • Provides strategies for weight management based on genetic make-up
  • Provides motivation to individuals with a goal to lose weight
     
  • Provides an understanding of why previous weight management programmes may have  been unsuccessful
     
  • Provides insight to which diet type (i.e. Mediterranean style, low carbohydrate, low fat diet) may be most suited to an individual to manage weight, based on genotype

The DNA Diet Test Report provides:

  • The level of impact of any genetic variants identified
  • An explanation of their impact on weight management
     
  • Appropriate nutritional and lifestyle recommendations.  This includes weight management priorities, diet plan principles, exercise planning and how to calculate MET hours
     


 

DNA Sport: Genetic markers for athletic fitness, performance, recovery and soft and connective tissue injury.  

DNA Sport examines various biological areas that impact training responsiveness and sporting performance. These include soft tissue and bone formation and remodelling; inflammation; oxidative stress; oxygenation influenced by blood flow and respiration; energy and fuel production; and metabolism during exercise. Knowledge of gene variations that influence these key biological areas can be used to exploit any genetic advantages and identify any weaknesses that need to be supported, through diet and the training strategies. 

Clinical Value

Suitable for the recreational athlete and the elite performance athlete, it provides information to optimise:

  • Power and endurance – physiological factors
  • Structural integrity – tendon pathology and injury risk
     
  • Recovery – training patterns and nutrition 

The DNA Sport Test Report provides:

  • The level of impact of any genetic variants identified
  • An explanation of their impact on sport performance, injury and recovery risk
     
  • Appropriate nutritional and lifestyle recommendations in relation to health and sports performance, including power and endurance, athletic potential and key training principles, injury and recovery​
     


 

DNA Oestrogen: Genetic markers for oestrogen biosynthesis, oestrogen metabolism, and phase I and phase II detoxification. 
 

DNA Oestrogen includes 11 genes involved in oestrogen biosynthesis, oestrogen metabolism, and phase I and phase II detoxification, providing information to guide personalised diet, lifestyle, hormone, and nutra-ceutical recommendations. 

Approximately 80% of breast cancer occurs in women with no family history.  Oestrogen affects the function of a number of target tissues and research has shown that an increased lifetime exposure to oestrogen is a strong risk factor in the development of breast cancer. DNA Oestrogen tests for gene variants that have been shown to have an impact on how oestrogen is metabolised. Guiding the personalisation of diet, hormone and nutritional supplement recommendations, based on the insight gained from the DNA Oestrogen test, to improve oestrogen metabolism is of benefit to men and women who suffer from numerous oestrogen-dominant conditions and who have higher lifetime exposure to oestrogens, oestrogen metabolites and other carcinogens. 

Clinical Value:

Recommended for:

  • Men or women with a strong family history of breast, ovarian, colon or prostate cancer
  • Women who suffer from oestrogen-dominant conditions such as endometriosis, premenstrual syndrome and uterine fibroid tumours
     
  • Women considering oral contraceptives, hormone replacement therapy or bio-identical hormone supplementation
     
  • Women who are considering in vitro fertilisation or who have been diagnosed with oestrogen  receptor-positive breast cancer
     

The DNA Oestrogen Test Report provides:

  • The level of impact of any genetic variants identified
  • An explanation of their impact on oestrogen metabolism
     
  • Appropriate nutritional and lifestyle recommendations to support healthy oestrogen metabolism

DNA Mind: Genes which have been shown to have significant associations with key mental health disorders.

According to research, neuropsychiatric disorders account for up to 25% of all disability-adjusted life years. Whilst the heritability of these mental disorders is significant, environmental factors also factor into their development. Genetic variations involved in key biological processes that contribute toward the risk of development of mental health disorders may give insights to the prevention, diagnosis and treatment of the disease.

By understanding an individual’s unique genetic makeup and predispositions, healthcare clinical professionals can better in developing strategies for individuals suffering from, or at risk of, mental health disorders.
 

The DNA Mind test analyses 30 genes which have been shown to have significant associations with key mental health disorders, and reports on the following areas:

  • Neurodegenerative disorders (Alzheimer’s disease, dementia, cognitive decline)
  • Addictive behaviour (A risk for alcohol, nicotine, cannabis & opioid dependence; Psychosis response from cannabis use; eating disorders (binge eating))
     
  • Adrenaline-seeking (Risk-taking behaviour)
     
  • Mood disorders (Depression, bipolar, anxiety and post-traumatic stress)

The DNA MindTest Report provides:
 

  • Identification of the level of impact of any genetic variants
  • An explanation of their impact on the specific biochemical area
     
  • An explanation of each area’s impact on mental health
     

Taking the test may help you, and/or your patients, understand ways that may avoid the onset of a range of neurological disorders.
 

Specimen Type: Saliva

TAT: 17 Days​
 

For more information about the test, please call 17237325 or 17237309 or 17237303​