Dr. Mahmoud A. M. Alfaqih
Dr. Mahmoud A. M. Alfaqih
Bio
Academic Background
Research Interests
Selected Publications
Bio
Dr. Mahmoud is an Associate Professor of Biochemistry and Molecular Biology. He received his PhD in Biochemistry from Washington State University/USA following a full scholarship awarded by the ministry of Higher Education in Jordan. Following his PhD, he trained in nuclear receptor pharmacology and drug discovery as a postdoctoral fellow at Duke University where he was granted a postdoctoral fellowship from the Department of Defense (DOD). Dr. Mahmoud’s research integrates cell and animal based experimental model systems with epidemiologic methods to facilitate the comprehension of the role of dietary and lifestyle factors in disease progression and treatment. Recently, he has become interested in Medical Education especially of how lifestyle factors affect academic performance. His research has appeared in Journals like; Nature Reviews Urology, Cancer Research, Molecular Cancer Research and Biomolecules. He is a member of the Endocrine Society.
Academic Background
• Postdoctoral Associate in Pharmacology and Cancer Biology, Duke University, 2010-2015
• Ph.D. in Biochemistry, Washington State University, 2008
• Bachelor of Dental Surgery, BDS, University of Jordan, 2002
Research Interests
• Lifestyle
• Nutrition
• Obesity
• Diabetes
• Cancer
Selected Publications
1. Alfaqih MA, Nelson ER, Liu W, et al. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017;77(7):1662-1673. doi:10.1158/0008-5472.CAN-16-2738
2. Dambal S, Alfaqih M, Sanders S, et al. 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. Mol Cancer Res. 2020;18(5):671-684. doi:10.1158/1541-7786.MCR-19-0974
3. Alfaqih MA, Allott EH, Hamilton RJ, Freeman MR, Freedland SJ. The current evidence on statin use and prostate cancer prevention: are we there yet?. Nat Rev Urol. 2017;14(2):107-119. doi:10.1038/nrurol.2016.199
4. Alfaqih MA, Ababneh E, Mhedat K, Allouh MZ. Vitamin D Reduces the Activity of Adenosine Deaminase and Oxidative Stress in Patients with Type Two Diabetes Mellitus. Mol Nutr Food Res. 2024;68(12):e2300870. doi:10.1002/mnfr.202300870
5. Alfaqih MA, Ababneh E, Khader Y, Mhedat K, Sater M. Higher Levels of Serum Leptin Are Linked with a Reduction in Gait Stability: A Sex-Based Association. Biomolecules. 2025;15(2):195. Published 2025 Jan 29. doi:10.3390/biom15020195